Tirzepatide 60mg (Single Vial)
Tirzepatide is a dual GIP and GLP-1 receptor agonist — a single molecule acting on two incretin pathways involved in glucose regulation, satiety signalling and energy balance. Supplied lyophilized and verified by third-party LC-MS.
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Product Details
| Purity | ≥99% (LC-MS verified) |
| Form | Lyophilized powder, preservative free |
| Storage | Cool and dry; refrigerate after reconstitution |
| Batch | COA available on request |
Why Choose Tirzepatide 60mg (Single Vial)?
Tirzepatide is a dual GIP and GLP-1 receptor agonist — a single molecule acting on two incretin pathways involved in glucose regulation, satiety signalling and energy balance. Supplied lyophilized and verified by third-party LC-MS.
Key Benefits
- Dual GIP / GLP-1 receptor agonist
- Third-party tested — COA available on request
- Lyophilized, preservative free
- Ships from the USA in discreet packaging
About Tirzepatide 60mg (Single Vial)
Tirzepatide is a dual agonist — a single 39-amino-acid synthetic peptide that binds both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the GLP-1 receptor. It was the first compound of its class to reach approval, and established that engaging two incretin pathways with one molecule produces a measurably different metabolic profile from GLP-1 agonism alone.
Supplied as lyophilized powder for laboratory research, preservative free, with third-party HPLC and LC-MS verification per lot.
Supplied for laboratory research use only. Not for human consumption.
Comparing this against the other one? Read the full retatrutide vs tirzepatide research comparison →
Receptor targets, development stage and the published evidence for both, side by side.
Research background
Dual incretin receptor engagement
Tirzepatide's defining feature is simultaneous activity at GIP and GLP-1 receptors. GIP had been comparatively neglected as a target; the trial results renewed research interest in its contribution to insulin secretion and adipose tissue metabolism.
Phase 3 trial programme
The SURPASS trials examined glycaemic endpoints and the SURMOUNT trials examined weight endpoints, both randomised and published in major journals. Several are open access and linked below.
Body composition analysis
A distinct strand of work uses imaging to separate fat mass from lean mass during weight reduction, addressing a question that simple weight endpoints cannot answer.
Comparative studies
Head-to-head and real-world comparative work against semaglutide is an active area, examining whether dual agonism produces different outcomes from single-receptor agonism at comparable exposures.
Tirzepatide is an approved medicine in several jurisdictions when supplied as a finished pharmaceutical product. Research-grade material is not a finished pharmaceutical and is not for human consumption.
Reconstitution
- Equilibrate firstAllow the vial to reach room temperature before opening. Introducing solvent into a cold vial promotes condensation, which affects both concentration accuracy and stability.
- Select the diluentBacteriostatic water — sterile water with 0.9% benzyl alcohol — is standard where the solution will be held for more than a few days. Plain sterile water is appropriate only for single-session use with no storage.
- Add slowly, down the wallDirect the solvent against the inner wall of the vial rather than onto the powder. A stream striking the lyophilized cake causes localized shear that can denature peptide chains.
- Do not shakeSwirl gently, or simply let the vial stand. Agitation introduces air and mechanical stress, and both degrade peptides. Full dissolution usually takes a minute or two.
- Inspect before useA correctly reconstituted solution is clear and colourless. Cloudiness, visible particulate or discolouration indicates a problem with the material or the diluent.
Concentration is set by the volume of diluent added. For a 10mg vial, 2mL of bacteriostatic water yields 5mg/mL. Calculate the working concentration your protocol requires rather than following a generic figure.
Storage and stability
| State | Temperature | Practical shelf life |
|---|---|---|
| Lyophilized, sealed | −20 °C | 24+ months |
| Lyophilized, sealed | 2–8 °C | ~12 months |
| Lyophilized, sealed | Room temperature | Weeks — transit only |
| Reconstituted, bacteriostatic water | 2–8 °C | ~3–4 weeks |
| Reconstituted, sterile water | 2–8 °C | Same session |
Lyophilized peptide is stable enough to survive shipping at ambient temperature, which is why cold-chain courier service is not required for transit. Long-term storage is a different matter — material intended to be held for months belongs in a freezer.
Protect from light, and avoid repeated freeze-thaw cycles. Each cycle causes measurable degradation, so dividing a reconstituted stock into single-use aliquots before freezing is preferable to thawing and refreezing one vial repeatedly.
Purity and verification
Every lot is tested by an independent laboratory using two orthogonal methods. HPLC (high-performance liquid chromatography) establishes purity as a percentage of total peptide content, separating the target compound from truncated sequences and synthesis by-products. LC-MS (liquid chromatography–mass spectrometry) confirms molecular identity by mass.
Both matter. Purity alone is insufficient — a 99% pure sample of the wrong compound is still the wrong compound. Together the two tests establish identity and quality, which is why Tirzepatide is released only after both pass.
The certificate of analysis references the lot number printed on your vial label. Request the COA for your lot at sales@pepsdepot.com.
Published research
Peer-reviewed studies indexed in PubMed. Each links to the abstract and, where a free copy exists, to the full text. We link primary sources rather than summarising them second-hand.
Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial
Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity
Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial
Frequently asked questions
How do you reconstitute tirzepatide?
What does 'dual agonist' actually mean?
How is tirzepatide supplied?
Does this need refrigerated shipping?
Is a certificate of analysis available?
Is Tirzepatide approved for human use?
Customer reviews
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