Semaglutide 10mg (Single Vial)
Semaglutide is a GLP-1 receptor agonist studied extensively for its role in glucose regulation, appetite signalling and metabolic research. Supplied lyophilized and verified by third-party LC-MS.
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Product Details
| Purity | ≥99% (LC-MS verified) |
| Form | Lyophilized powder, preservative free |
| Storage | Cool and dry; refrigerate after reconstitution |
| Batch | COA available on request |
Why Choose Semaglutide 10mg (Single Vial)?
Semaglutide is a GLP-1 receptor agonist studied extensively for its role in glucose regulation, appetite signalling and metabolic research. Supplied lyophilized and verified by third-party LC-MS.
Key Benefits
- GLP-1 receptor agonist research compound
- Third-party tested — COA available on request
- Lyophilized, preservative free
- Ships from the USA in discreet packaging
About Semaglutide 10mg (Single Vial)
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist — a modified analogue of the naturally occurring incretin hormone GLP-1, engineered with a fatty-acid side chain that binds albumin and extends its circulating half-life from minutes to roughly a week.
It is among the most extensively studied metabolic compounds of the last decade, with large randomised trials published in NEJM, JAMA and Nature Medicine. Supplied here as lyophilized powder for laboratory research, verified by third-party HPLC and LC-MS.
Supplied for laboratory research use only. Not for human consumption.
Research background
GLP-1 receptor agonism
Semaglutide binds the GLP-1 receptor, a G-protein-coupled receptor expressed in pancreatic islet cells, the gastrointestinal tract and regions of the central nervous system involved in appetite regulation. Receptor binding drives the glucose-dependent insulin response that defines the incretin class.
Gastric emptying and satiety signalling
A consistent finding across the literature is delayed gastric emptying alongside central satiety signalling, examined in both animal models and human trials as the mechanism behind reduced energy intake.
Randomised controlled trial evidence
Unlike most compounds in this catalogue, semaglutide has a substantial human trial literature — the STEP programme for weight, SUSTAIN for glycaemic endpoints, and SELECT for cardiovascular outcomes. The studies linked below are peer-reviewed and open access.
Half-life engineering
The structural modifications — amino-acid substitution at position 8 to resist DPP-4 degradation, plus a C18 fatty di-acid linker for albumin binding — are themselves a subject of pharmacokinetic study, and the template for later incretin analogues.
Semaglutide is an approved medicine in several jurisdictions when supplied as a finished pharmaceutical product. Material supplied as a research reference compound is not a finished pharmaceutical and is not for human consumption.
Reconstitution
- Equilibrate firstAllow the vial to reach room temperature before opening. Introducing solvent into a cold vial promotes condensation, which affects both concentration accuracy and stability.
- Select the diluentBacteriostatic water — sterile water with 0.9% benzyl alcohol — is standard where the solution will be held for more than a few days. Plain sterile water is appropriate only for single-session use with no storage.
- Add slowly, down the wallDirect the solvent against the inner wall of the vial rather than onto the powder. A stream striking the lyophilized cake causes localized shear that can denature peptide chains.
- Do not shakeSwirl gently, or simply let the vial stand. Agitation introduces air and mechanical stress, and both degrade peptides. Full dissolution usually takes a minute or two.
- Inspect before useA correctly reconstituted solution is clear and colourless. Cloudiness, visible particulate or discolouration indicates a problem with the material or the diluent.
Concentration is set by the volume of diluent added. For a 5mg vial, 2mL of bacteriostatic water yields 2.5mg/mL. Calculate the working concentration your protocol requires rather than following a generic figure.
Storage and stability
| State | Temperature | Practical shelf life |
|---|---|---|
| Lyophilized, sealed | −20 °C | 24+ months |
| Lyophilized, sealed | 2–8 °C | ~12 months |
| Lyophilized, sealed | Room temperature | Weeks — transit only |
| Reconstituted, bacteriostatic water | 2–8 °C | ~3–4 weeks |
| Reconstituted, sterile water | 2–8 °C | Same session |
Lyophilized peptide is stable enough to survive shipping at ambient temperature, which is why cold-chain courier service is not required for transit. Long-term storage is a different matter — material intended to be held for months belongs in a freezer.
Protect from light, and avoid repeated freeze-thaw cycles. Each cycle causes measurable degradation, so dividing a reconstituted stock into single-use aliquots before freezing is preferable to thawing and refreezing one vial repeatedly.
Purity and verification
Every lot is tested by an independent laboratory using two orthogonal methods. HPLC (high-performance liquid chromatography) establishes purity as a percentage of total peptide content, separating the target compound from truncated sequences and synthesis by-products. LC-MS (liquid chromatography–mass spectrometry) confirms molecular identity by mass.
Both matter. Purity alone is insufficient — a 99% pure sample of the wrong compound is still the wrong compound. Together the two tests establish identity and quality, which is why Semaglutide is released only after both pass.
The certificate of analysis references the lot number printed on your vial label. Request the COA for your lot at sales@pepsdepot.com.
Published research
Peer-reviewed studies indexed in PubMed. Each links to the abstract and, where a free copy exists, to the full text. We link primary sources rather than summarising them second-hand.
Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial
Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial
Frequently asked questions
How do you reconstitute semaglutide?
How does semaglutide differ from tirzepatide?
Why does semaglutide have more human data than most research peptides?
Does this need refrigerated shipping?
Is a certificate of analysis available?
Is Semaglutide approved for human use?
Customer reviews
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