IGF-1 LR3 10mg Kit
IGF-1 LR3 is a long-arginine analog of insulin-like growth factor 1, modified for extended half-life and reduced binding-protein affinity. Supplied lyophilized and third-party verified.
- ✅ Order today › 📦 Dispatch (2 business days) › 🚚 Delivery (3–9 business days)
- 🧪 Most lab-tested source in the industry
- ⭐ 500+ reviews across independent platforms
- 🔒 Secure checkout — Crypto, Cash App & Venmo
- 📦 Discreet packaging, guaranteed delivery
Product Details
| Purity | ≥99% (LC-MS verified) |
| Form | Lyophilized powder, preservative free |
| Storage | Cool and dry; refrigerate after reconstitution |
| Batch | COA available on request |
Why Choose IGF-1 LR3 10mg Kit?
IGF-1 LR3 is a long-arginine analog of insulin-like growth factor 1, modified for extended half-life and reduced binding-protein affinity. Supplied lyophilized and third-party verified.
Key Benefits
- Long R3 insulin-like growth factor analog
- Third-party tested — COA available on request
- Lyophilized, preservative free
- Ships from the USA in discreet packaging
About IGF-1 LR3 10mg Kit
IGF-1 LR3 (Long R3 insulin-like growth factor 1) is an engineered analogue of human IGF-1, modified in two ways: an arginine substitution at position 3, and a 13-amino-acid extension at the N-terminus. Both changes serve the same purpose — reducing affinity for IGF-binding proteins.
Native IGF-1 circulates almost entirely bound to binding proteins, which regulate its availability. The LR3 modifications reduce that binding substantially, which extends the analogue's active half-life relative to native IGF-1 and is why it is preferred in research settings where sustained receptor exposure is required.
Supplied for laboratory research use only. Not for human consumption.
Research background
Binding-protein evasion
The defining property of LR3 is reduced affinity for IGF-binding proteins 1 through 6. Since these proteins normally sequester the majority of circulating IGF-1, reduced binding leaves more analogue available to engage receptors.
IGF-1 receptor signalling
IGF-1 binds a receptor tyrosine kinase closely related to the insulin receptor, activating the PI3K/Akt and MAPK cascades — pathways central to cell growth, protein synthesis and survival signalling.
Cell culture applications
IGF-1 LR3 is widely used as a supplement in mammalian cell culture media, where its binding-protein resistance makes it more consistent than native IGF-1. This is one of its most established laboratory applications.
Muscle and metabolic models
Animal and in vitro work has examined protein synthesis signalling in muscle tissue and glucose handling, reflecting the receptor's overlap with insulin signalling.
IGF-1 LR3 is a research reagent and cell-culture supplement. It is not an approved drug and has no approved human use.
Reconstitution
- Equilibrate firstAllow the vial to reach room temperature before opening. Introducing solvent into a cold vial promotes condensation, which affects both concentration accuracy and stability.
- Select the diluentBacteriostatic water — sterile water with 0.9% benzyl alcohol — is standard where the solution will be held for more than a few days. Plain sterile water is appropriate only for single-session use with no storage.
- Add slowly, down the wallDirect the solvent against the inner wall of the vial rather than onto the powder. A stream striking the lyophilized cake causes localized shear that can denature peptide chains.
- Do not shakeSwirl gently, or simply let the vial stand. Agitation introduces air and mechanical stress, and both degrade peptides. Full dissolution usually takes a minute or two.
- Inspect before useA correctly reconstituted solution is clear and colourless. Cloudiness, visible particulate or discolouration indicates a problem with the material or the diluent.
Concentration is set by the volume of diluent added. For a 1mg vial, 1mL of bacteriostatic water yields 1mg/mL. Calculate the working concentration your protocol requires rather than following a generic figure.
Storage and stability
| State | Temperature | Practical shelf life |
|---|---|---|
| Lyophilized, sealed | −20 °C | 24+ months |
| Lyophilized, sealed | 2–8 °C | ~12 months |
| Lyophilized, sealed | Room temperature | Weeks — transit only |
| Reconstituted, bacteriostatic water | 2–8 °C | ~3–4 weeks |
| Reconstituted, sterile water | 2–8 °C | Same session |
Lyophilized peptide is stable enough to survive shipping at ambient temperature, which is why cold-chain courier service is not required for transit. Long-term storage is a different matter — material intended to be held for months belongs in a freezer.
Protect from light, and avoid repeated freeze-thaw cycles. Each cycle causes measurable degradation, so dividing a reconstituted stock into single-use aliquots before freezing is preferable to thawing and refreezing one vial repeatedly.
Purity and verification
Every lot is tested by an independent laboratory using two orthogonal methods. HPLC (high-performance liquid chromatography) establishes purity as a percentage of total peptide content, separating the target compound from truncated sequences and synthesis by-products. LC-MS (liquid chromatography–mass spectrometry) confirms molecular identity by mass.
Both matter. Purity alone is insufficient — a 99% pure sample of the wrong compound is still the wrong compound. Together the two tests establish identity and quality, which is why IGF-1 LR3 is released only after both pass.
The certificate of analysis references the lot number printed on your vial label. Request the COA for your lot at sales@pepsdepot.com.
Published research
Peer-reviewed studies indexed in PubMed. Each links to the abstract and, where a free copy exists, to the full text. We link primary sources rather than summarising them second-hand.
Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis
Exercise-induced modulation of IGF-1 in healthy, obese, and cancer populations: a systematic review and meta-analysis
The cell biology of systemic insulin function
Frequently asked questions
How do you reconstitute IGF-1 LR3?
Why is LR3 used instead of native IGF-1?
Why are vial sizes so much smaller than other peptides?
Does this need refrigerated shipping?
Is a certificate of analysis available?
Is IGF-1 LR3 approved for human use?
Customer reviews
Related compounds
Compounds studied alongside this one, or acting through related pathways.
Related products
